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Science 20 October 1995:
Vol. 270. no. 5235, pp. 397 - 404
DOI: 10.1126/science.270.5235.397
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Articles

The Minimal Gene Complement of Mycoplasma genitalium

Claire M. Fraser (1),  Jeannine D. Gocayne,  Owen White,  Mark D. Adams,  Rebecca A. Clayton,  Robert D. Fleischmann,  Carol J. Bult,  Anthony R. Kerlavage,  Granger Sutton,  Jenny M. Kelley,  Janice L. Fritchman,  Janice F. Weidman,  Keith V. Small,  Mina Sandusky,  Joyce Fuhrmann,  David Nguyen,  Teresa R. Utterback,  Deborah M. Saudek,  Cheryl A. Phillips,  Joseph M. Merrick,  Jean-Francois Tomb,  Brian A. Dougherty,  Kenneth F. Bott,  Ping-Chuan Hu,  Thomas S. Lucier,  Scott N. Peterson,  Hamilton O. Smith,  Clyde A. Hutchison III,  J. Craig Venter

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.


C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, and J. C. Venter are at the Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. J. M. Merrick is in the Department of Microbiology, State University of New York at Buffalo, Buffalo, NY 14214, USA. J.-F. Tomb, B. A. Dougherty and H. O. Smith are at the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. K. F. Bott, P.-C. Hu, T. S. Lucier, S. N. Peterson, and C. A. Hutchison III are at the University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, USA.
(1) To whom correspondence should be addressed.


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{sigma} Factors and Global Gene Regulation in Mycobacterium tuberculosis.
R. Manganelli, R. Proveddi, S. Rodrigue, J. Beaucher, L. Gaudreau, and I. Smith (2004)
J. Bacteriol. 186, 895-902
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Determination of Infectious Load of Mycoplasma genitalium in Clinical Samples of Human Vaginal Cells.
M. W. Blaylock, O. Musatovova, J. G. Baseman, and J. B. Baseman (2004)
J. Clin. Microbiol. 42, 746-752
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The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP).
J. Westberg, A. Persson, A. Holmberg, A. Goesmann, J. Lundeberg, K.-E. Johansson, B. Pettersson, and M. Uhlen (2004)
Genome Res. 14, 221-227
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Science. ISSN 0036-8075 (print), 1095-9203 (online)