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Science 8 December 1995:
Vol. 270. no. 5242, pp. 1595 - 1601
DOI: 10.1126/science.270.5242.1595
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Special

Chromosomal Control of Meiotic Cell Division

Kim S. McKim and R. Scott Hawley (1)

Chromosomes have multiple roles both in controlling the cell assembly and structure of the spindle and in determining chromosomal position on the spindle in many meiotic cells and in some types of mitotic cells. Moreover, functionally significant chromosome-microtubule interactions are not limited to the kinetochore but are also mediated by proteins localized along the arms of chromosomes. Finally, chromosomes also play a crucial role in control of the cell cycle.


The authors are in the Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA.
(1) To whom correspondence should be addressed.


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Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules.
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Aurora A Phosphorylates MCAK to Control Ran-dependent Spindle Bipolarity.
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Spindle assembly in the absence of chromosomes in mouse oocytes.
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Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators.
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The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster.
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J. Cell Biol. 171, 593-602
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The Kinesinlike Protein Subito Contributes to Central Spindle Assembly and Organization of the Meiotic Spindle in Drosophila Oocytes.
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A perfect funeral with no corpse.
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Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.
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subito Encodes a Kinesin-like Protein Required for Meiotic Spindle Pole Formation in Drosophila melanogaster.
K. L. Giunta, J. K. Jang, E. A. Manheim, G. Subramanian, and K. S. McKim (2002)
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The centrosome is a dynamic structure that ejects PCM flares.
T. L. Megraw, S. Kilaru, F. R. Turner, and T. C. Kaufman (2002)
J. Cell Sci. 115, 4707-4718
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Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts.
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J. Cell Biol. 153, 149-158
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Dis1/TOG universal microtubule adaptors - one MAP for all?.
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J. Cell Sci. 114, 3805-3812
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The Drosophila wispy Gene Is Required for RNA Localization and Other Microtubule-Based Events of Meiosis and Early Embryogenesis.
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The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle.
V. Mountain, C. Simerly, L. Howard, A. Ando, G. Schatten, and D. A. Compton (1999)
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mini spindles: A Gene Encoding a Conserved Microtubule-Associated Protein Required for the Integrity of the Mitotic Spindle in Drosophila.
C. F. Cullen, P. Deak, D. M. Glover, and H. Ohkura (1999)
J. Cell Biol. 146, 1005-1018
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Nuclear Organization and Chromosome Segregation.
A. E. Franklin and W. Z. Cande (1999)
PLANT CELL 11, 523-534
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The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila.
T. Megraw, K Li, L. Kao, and T. Kaufman (1999)
Development 126, 2829-2839
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Dynein is required for spindle assembly in cytoplasmic extracts of Spisula solidissima oocytes.
R. Palazzo, E. Vaisberg, D. Weiss, S. Kuznetsov, and W Steffen (1999)
J. Cell Sci. 112, 1291-1302
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CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.
D. Stuart and C. Wittenberg (1998)
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Spindle Assembly and Mitosis without Centrosomes in Parthenogenetic Sciara Embryos.
B. de Saint Phalle and W. Sullivan (1998)
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Maize meiotic spindles assemble around chromatin and do not require paired chromosomes.
A Chan and W. Cande (1998)
J. Cell Sci. 111, 3507-3515
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Focusing on spindle poles.
D. Compton (1998)
J. Cell Sci. 111, 1477-1481
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Lack of Checkpoint Control at the Metaphase/Anaphase Transition: A Mechanism of Meiotic Nondisjunction in Mammalian Females.
R. LeMaire-Adkins, K. Radke, and P. A. Hunt (1997)
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The Yeast Motor Protein, Kar3p, Is Essential for Meiosis I.
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Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes.
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Spindle Assembly in Xenopus Egg Extracts: Respective Roles of Centrosomes and Microtubule Self-Organization.
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Role of microtubules and microtubule organizing centers on meiotic chromosome elimination in Sciara ocellaris.
M. Esteban, M. Campos, A. Perondini, and C Goday (1997)
J. Cell Sci. 110, 721-730
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Incomplete sister chromatid separation is the mechanism of programmed chromosome elimination during early Sciara coprophila embryogenesis.
B de Saint Phalle and W Sullivan (1996)
Development 122, 3775-3784
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Meiotic spindle organization in fertilized Drosophila oocyte: presence of centrosomal components in the meiotic apparatus.
M. Riparbelli and G Callaini (1996)
J. Cell Sci. 109, 911-918
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Science. ISSN 0036-8075 (print), 1095-9203 (online)