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Science 15 March 1996:
Vol. 271. no. 5255, pp. 1526 - 1533
DOI: 10.1126/science.271.5255.1526
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Articles

Coat Proteins and Vesicle Budding

Randy Schekman * and Lelio Orci

The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving compartment. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.

R. Schekman is in the Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720-3202, USA. L. Orci is at the Department of Morphology, Faculty of Medicine, University of Geneva, Geneva 4, CH-1211 Switzerland.
* To whom correspondence should be addressed.


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J. Virol. 75, 9808-9818
   Abstract »    Full Text »    PDF »
The Coatomer-interacting Protein Dsl1p Is Required for Golgi-to-Endoplasmic Reticulum Retrieval in Yeast.
U. Andag, T. Neumann, and H. D. Schmitt (2001)
J. Biol. Chem. 276, 39150-39160
   Abstract »    Full Text »    PDF »
Association of ARF and Rabs with complement receptor Type-1 storage vesicles in human neutrophils.
S. Chaudhuri, A. Kumar, and M. Berger (2001)
J. Leukoc. Biol. 70, 669-676
   Abstract »    Full Text »    PDF »
Microsomal membrane-associated apoB is the direct precursor of secreted VLDL in primary cultures of rat hepatocytes.
A.-M. Hebbachi and G. F. Gibbons (2001)
J. Lipid Res. 42, 1609-1617
   Abstract »    Full Text »    PDF »
Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.
G. Z. Lederkremer, Y. Cheng, B. M. Petre, E. Vogan, S. Springer, R. Schekman, T. Walz, and T. Kirchhausen (2001)
PNAS
   Abstract »    Full Text »    PDF »
Biogenesis of Golgi Stacks in Imaginal Discs of Drosophila melanogaster.
V. Kondylis, S. E. Goulding, J. C. Dunne, and C. Rabouille (2001)
Mol. Biol. Cell 12, 2308-2327
   Abstract »    Full Text »    PDF »
AP-3 Mediates Tyrosinase but Not TRP-1 Trafficking in Human Melanocytes.
M. Huizing, R. Sarangarajan, E. Strovel, Y. Zhao, W. A. Gahl, and R. E. Boissy (2001)
Mol. Biol. Cell 12, 2075-2085
   Abstract »    Full Text »    PDF »
An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization.
Y. Mazaki, S. Hashimoto, K. Okawa, A. Tsubouchi, K. Nakamura, R. Yagi, H. Yano, A. Kondo, A. Iwamatsu, A. Mizoguchi, et al. (2001)
Mol. Biol. Cell 12, 645-662
   Abstract »    Full Text »
Erv41p and Erv46p: New Components of Copii Vesicles Involved in Transport between the ER and Golgi Complex.
S. Otte, W. J. Belden, M. Heidtman, J. Liu, O. N. Jensen, and C. Barlowe (2001)
J. Cell Biol. 152, 503-518
   Abstract »    Full Text »    PDF »


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