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Science 15 March 1996:
Vol. 271. no. 5255, pp. 1539 - 1544
DOI: 10.1126/science.271.5255.1539
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Articles

Targeting of Motor Proteins

Richard B. Vallee and Michael P. Sheetz

Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules. How these proteins are targeted to the appropriate organellar sites within the cell, however, has remained a mystery. Recent work has begun to define the targeting mechanism for two well-studied motor proteins, kinesin and cytoplasmic dynein.

R. B. Vallee is at the Worcester Foundation for Biomedical Research, 222 Maple Avenue, Shrewsbury, MA 01545, USA. M. P. Sheetz is in the Department of Cell Biology, Duke University, Durham, NC 27710, USA.


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The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport.
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Overexpression of the Dynamitin (p50) Subunit of the Dynactin Complex Disrupts Dynein-dependent Maintenance of Membrane Organelle Distribution.
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J. Cell Biol. 139, 469-484
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Kinesin- and Myosin-driven Steps of Vesicle Recruitment for Ca2+-regulated Exocytosis.
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Phosphorylation by p34cdc2 Protein Kinase Regulates Binding of the Kinesin-related Motor HsEg5 to the Dynactin Subunit p150Glued.
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Light Intermediate Chain 1 Defines a Functional Subfraction of Cytoplasmic Dynein Which Binds to Pericentrin.
S. H. Tynan, A. Purohit, S. J. Doxsey, and R. B. Vallee (2000)
J. Biol. Chem. 275, 32763-32768
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Distinct but Overlapping Sites within the Cytoplasmic Dynein Heavy Chain for Dimerization and for Intermediate Chain and Light Intermediate Chain Binding.
S. H. Tynan, M. A. Gee, and R. B. Vallee (2000)
J. Biol. Chem. 275, 32769-32774
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Protein Kinase C-regulated Dynamitin-Macrophage-enriched Myristoylated Alanine-Rice C Kinase Substrate Interaction Is Involved in Macrophage Cell Spreading.
L. Yue, S. Lu, J. Garces, T. Jin, and J. Li (2000)
J. Biol. Chem. 275, 23948-23956
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The 8-kDa Dynein Light Chain Binds to Its Targets via a Conserved (K/R)XTQT Motif.
K. W.-H. Lo, S. Naisbitt, J.-S. Fan, M. Sheng, and M. Zhang (2001)
J. Biol. Chem. 276, 14059-14066
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In Vivo Interaction between Dynamitin and MacMARCKS Detected by the Fluorescent Resonance Energy Transfer Method.
T. Jin, L. Yue, and J. Li (2001)
J. Biol. Chem. 276, 12879-12884
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Structure of Tctex-1 and Its Interaction with Cytoplasmic Dynein Intermediate Chain.
Y.-K. Mok, K. W.-H. Lo, and M. Zhang (2001)
J. Biol. Chem. 276, 14067-14074
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Phosphorylation by cdc2-CyclinB1 Kinase Releases Cytoplasmic Dynein from Membranes.
S. G. Addinall, P. S. Mayr, S. Doyle, J. K. Sheehan, P. G. Woodman, and V. J. Allan (2001)
J. Biol. Chem. 276, 15939-15944
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Cytoplasmic Dynein Intermediate Chain Phosphorylation Regulates Binding to Dynactin.
P. S. Vaughan, J. D. Leszyk, and K. T. Vaughan (2001)
J. Biol. Chem. 276, 26171-26179
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Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.
J. Huang, T. Imamura, and J. M. Olefsky (2001)
PNAS 98, 13084-13089
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