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Science 5 July 1996:
Vol. 273. no. 5271, pp. 70 - 74
DOI: 10.1126/science.273.5271.70
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Articles

The Aging Immune System: Primer and Prospectus

Richard A. Miller

Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.

The author is at the University of Michigan School of Medicine, University of Michigan Institute of Gerontology, and Ann Arbor Department of Veterans' Affairs Medical Center, Ann Arbor, MI 48109-0642, USA.


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JAMA 292, 1333-1340
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Senescent BALB/c Mice Are Able To Develop Resistance to Leishmania major Infection.
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Infect. Immun. 72, 5106-5114
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J. Exp. Med. 200, 411-423
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Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression.
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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly.
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PNAS 100, 15053-15058
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Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans.
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J. Lipid Res. 44, 2304-2310
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J. Gerontol. A Biol. Sci. Med. Sci. 58, B1063-1073
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Mol. Endocrinol. 17, 2386-2392
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V. Jankovic, I. Messaoudi, and J. Nikolich-Zugich (2003)
Blood 102, 3244-3251
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Ingestion of a Dietary Supplement Containing Dehydroepiandrosterone (DHEA) and Androstenedione Has Minimal Effect on Immune Function in Middle-Aged Men.
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J. Am. Coll. Nutr. 22, 363-371
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Blood 102, 1397-1404
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Inflammatory Cytokine Response to Vibrio vulnificus Elicited by Peripheral Blood Mononuclear Cells from Chronic Alcohol Users Is Associated with Biomarkers of Cellular Oxidative Stress.
J. L. Powell, K. A. Strauss, C. Wiley, M. Zhan, and J. G. Morris Jr. (2003)
Infect. Immun. 71, 4212-4216
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Effects of an Exercise Intervention on Immunologic Parameters in Frail Elderly Nursing Home Residents.
Z. F. Kapasi, J. G. Ouslander, J. F. Schnelle, M. Kutner, and J. L. Fahey (2003)
J. Gerontol. A Biol. Sci. Med. Sci. 58, M636-643
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L. Dong, I. Mori, Md. J. Hossain, B. Liu, and Y. Kimura (2003)
J. Gen. Virol. 84, 1623-1628
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Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-kappa B Activity.
D. Wu, M. Marko, K. Claycombe, K. E. Paulson, and S. N. Meydani (2003)
J. Biol. Chem. 278, 10983-10992
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CD4+CD25- T Cells in Aged Mice Are Hyporesponsive and Exhibit Suppressive Activity.
J. Shimizu and E. Moriizumi (2003)
J. Immunol. 170, 1675-1682
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Protective Mucosal Immunity in Aging Is Associated with Functional CD4+ T Cells in Nasopharyngeal-Associated Lymphoreticular Tissue.
Y. Hagiwara, J. R. McGhee, K. Fujihashi, R. Kobayashi, N. Yoshino, K. Kataoka, Y. Etani, M.-N. Kweon, S. Tamura, T. Kurata, et al. (2003)
J. Immunol. 170, 1754-1762
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Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions.
H. Kato, K. Fujihashi, R. Kato, T. Dohi, K. Fujihashi, Y. Hagiwara, K. Kataoka, R. Kobayashi, and J. R. McGhee (2003)
Int. Immunol. 15, 145-158
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Robustness Into Advanced Age of Atopy-Specific Mechanisms in Atopy-Prone Families.
D. R. Jackola, L. K. Pierson-Mullany, L. R. Daniels, E. Corazalla, A. Rosenberg, and M. N. Blumenthal (2003)
J. Gerontol. A Biol. Sci. Med. Sci. 58, B99-107
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Aging and developmental transitions in the B cell lineage.
K. M. Johnson, K. Owen, and P. L. Witte (2002)
Int. Immunol. 14, 1313-1323
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Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging.
M. Renshaw, J. Rockwell, C. Engleman, A. Gewirtz, J. Katz, and S. Sambhara (2002)
J. Immunol. 169, 4697-4701
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Repertoire of Antibody Response in Bone Marrow and the Memory Response Are Differentially Affected in Aging Mice.
Y.-F. Lu and J. Cerny (2002)
J. Immunol. 169, 4920-4927
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Defective T Cell Priming Associated with Aging Can Be Rescued by Signaling Through 4-1BB (CD137).
P. Bansal-Pakala and M. Croft (2002)
J. Immunol. 169, 5005-5009
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Exercise and Psychosocial Factors Modulate Immunity to Influenza Vaccine in Elderly Individuals.
M. L. Kohut, M. M. Cooper, M. S. Nickolaus, D. R. Russell, and J. E. Cunnick (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, M557-562
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Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial.
J. M. Graat, E. G. Schouten, and F. J. Kok (2002)
JAMA 288, 715-721
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Altered Memory B-Cell Homeostasis in Human Aging.
E. Breitbart, X. Wang, L. S. Leka, G. E. Dallal, S. N. Meydani, and B. D. Stollar (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B304-311
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Numerical and functional alterations of circulating {gamma}{delta} T lymphocytes in aged people and centenarians.
K. Argentati, F. Re, A. Donnini, M. G. Tucci, C. Franceschi, B. Bartozzi, G. Bernardini, and M. Provinciali (2002)
J. Leukoc. Biol. 72, 65-71
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Blood-Sample Processing for the Study of Age-Dependent Gene Expression in Peripheral Blood Mononuclear Cells.
C. Lacelle, H. Riol, S. Xu, Y.-J. Tang, Y.-S. Wang, Y.-L. Chuang, H.-S. Lin, M.-C. Chang, J. Liang, and E. Wang (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B285-287
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Early Antigen-Specific Response by Naive CD8 T Cells Is Not Altered with Aging.
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Bacterial Superantigen Exposure after Resolution of Influenza Virus Infection Perturbs the Virus-Specific Memory CD8+-T-Cell Repertoire.
C.-C. Huang, S. Shah, P. Nguyen, J. D. Altman, and M. A. Blackman (2002)
J. Virol. 76, 6852-6856
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P. R. Heaton, D. G. Blount, S. J. Mann, P. Devlin, S. Koelsch, B. H. E. Smith, J. Stevenson, E. J. Harper, and J. M. Rawlings (2002)
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P. R. Heaton, D. G. Blount, P. Devlin, S. Koelsch, S. J. Mann, B. H. E. Smith, J. Stevenson, and E. J. Harper (2002)
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Diagnosis of Respiratory Syncytial Virus Infection: Comparison of Reverse Transcription-PCR to Viral Culture and Serology in Adults with Respiratory Illness.
A. R. Falsey, M. A. Formica, and E. E. Walsh (2002)
J. Clin. Microbiol. 40, 817-820
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Fatal Inhalational Anthrax in a 94-Year-Old Connecticut Woman.
L. A. Barakat, H. L. Quentzel, J. A. Jernigan, D. L. Kirschke, K. Griffith, S. M. Spear, K. Kelley, D. Barden, D. Mayo, D. S. Stephens, et al. (2002)
JAMA 287, 863-868
   Abstract »    Full Text »    PDF »
Changes in Proinflammatory Cytokine Activity after Menopause.
J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz (2002)
Endocr. Rev. 23, 90-119
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Age-Associated Loss of Bone Marrow Hematopoietic Cells Is Reversed by GH and Accompanies Thymic Reconstitution.
R. A. French, S. R. Broussard, W. A. Meier, C. Minshall, S. Arkins, J. F. Zachary, R. Dantzer, and K. W. Kelley (2002)
Endocrinology 143, 690-699
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Defect in ERK2 and p54JNK Activation in Aging Mouse Splenocytes.
M. Li, C. Torres, C. Acuna-Castillo, R. Walter, E. M. Gardner, D. M. Murasko, and F. Sierra (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B41-47
   Abstract »    Full Text »


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