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Science 10 July 2009:
Vol. 325. no. 5937, pp. 210 - 213
DOI: 10.1126/science.1173215
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Reports

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

C. D. Clelland,1,2 M. Choi,2 C. Romberg,3 G. D. Clemenson, Jr.,1 A. Fragniere,2 P. Tyers,2 S. Jessberger,4 L. M. Saksida,3,5 R. A. Barker,2,6,* F. H. Gage,1,*,{dagger} T. J. Bussey3,5,*,{dagger}

The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation—the formation of distinct and orthogonal representations of mnemonic information—and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice.

1 Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
2 Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK.
3 Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
4 Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
5 Medical Research Council and Wellcome Trust Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
6 Department of Neurology, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: gage{at}salk.edu (F.H.G.); tjb1000{at}cam.ac.uk (T.J.B.)

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