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Science 1 December 1995:
Vol. 270. no. 5241, pp. 1485 - 1488
DOI: 10.1126/science.270.5241.1485
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Reports

Autoencapsulation Through Intermolecular Forces: A Synthetic Self-Assembling Spherical Complex

Robert S. Meissner,  Julius Rebek Jr. (1),  Javier de Mendoza

The synthesis and characterization of a system for the study of molecular recognition phenomena are described. The system involves a tetraurea molecule that is capable of assembly into various associated states through hydrogen bonding. In organic solvents, the dynamic transition between a low-ordered (aggregate) state and a highly ordered dimeric assembly can be induced by the introduction of smaller molecules of appropriate size and shape. These smaller molecules, such as benzene, adamantanes, and ferrocenes, act as guests that occupy the pseudospherical capsule formed by the dimeric host. Among various guests, those that best fill the cavity and offer chemical complementarity to the host are preferentially encapsulated.


R. S. Meissner and J. Rebek Jr., Massachusetts Institute of Technology, Department of Chemistry, Cambridge, MA 02139, USA.
J. de Mendoza, Universidad Autonoma de Madrid, Departamento de Quimica, Cantoblanco, 28049 Madrid, Spain.
(1) To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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