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Science 12 January 1996: Vol. 271. no. 5246, pp. 173 - 178 DOI: 10.1126/science.271.5246.173
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Articles
Immunology Taught by Viruses
Rolf M. Zinkernagel
The survival of viruses depends on the survival of susceptible
hosts. The vertebrate immune system and viruses have therefore
coevolved complementary facets. Evidence from various balanced
virus-host relationships illustrates that immunological specificity and
memory may best be defined biologically and that the mature immune
system does not discriminate between ``self'' and
``nonself.''
Rather, B cells distinguish antigen patterns, whereas T cell responses
depend on localization, transport, and kinetics of antigen within
lymphatic organs.
The author is at the Institute of Experimental Immunology,
University of Zurich, Schmelzbergstrasse 12,CH-8091 Zurich,
Switzerland.
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