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Science 12 January 1996:
Vol. 271. no. 5246, pp. 198 - 200
DOI: 10.1126/science.271.5246.198
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Reports

A Role for CD81 in Early T Cell Development

Richard Boismenu,  Maria Rhein,  Wolfgang H. Fischer,  Wendy L. Havran (1)

Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of alphabeta but not T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4-CD8- thymocytes differentiated into CD4CD8 T cells. Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development.


R. Boismenu, M. Rhein, W. L. Havran, Department of Immunology, Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA.
W. H. Fischer, Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037, USA.
(1) To whom correspondence should be addressed.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)