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Science 15 March 1996:
Vol. 271. no. 5255, pp. 1533 - 1539
DOI: 10.1126/science.271.5255.1533
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Articles

Phosphoinositides as Regulators in Membrane Traffic

Pietro De Camilli, * Scott D. Emr, Peter S. McPherson, Peter Novick

Phosphorylated products of phosphatidylinositol play critical roles in the regulation of membrane traffic, in addition to their classical roles as second messengers in signal transduction at the cell surface. Growing evidence suggests that phosphorylation-dephosphorylation of the polar heads of phosphoinositides (polyphosphorylated inositol lipids) in specific intracellular locations signals either the recruitment or the activation of proteins essential for vesicular transport. Cross talk between phosphatidylinositol metabolites and guanosine triphosphatases is an important feature of these regulatory mechanisms.

P. De Camilli is at the Howard Hughes Medical Institute and in the Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA. S. D. Emr is at the Howard Hughes Medical Institute and in the Division of Cellular and Molecular Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA. P. S. McPherson is at the Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada. P. Novick is in the Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
* To whom correspondence should be addressed. E-mail: pietro_decamilli{at}quickmail.yale.edu


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Convergence of Fc{gamma} Receptor IIA and Fc{gamma} Receptor IIIB Signaling Pathways in Human Neutrophils.
F. Y. S. Chuang, M. Sassaroli, and J. C. Unkeless (2000)
J. Immunol. 164, 350-360
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Selective Alterations in Biosynthetic and Endocytic Protein Traffic in Madin-Darby Canine Kidney Epithelial Cells Expressing Mutants of the Small GTPase Rac1.
T.-S. Jou, S.-M. Leung, L. M. Fung, W. G. Ruiz, W. J. Nelson, and G. Apodaca (2000)
Mol. Biol. Cell 11, 287-304
   Abstract »    Full Text »
Salinity and Hyperosmotic Stress Induce Rapid Increases in Phosphatidylinositol 4,5-Bisphosphate, Diacylglycerol Pyrophosphate, and Phosphatidylcholine in Arabidopsis thaliana Cells.
C. Pical, T. Westergren, S. K. Dove, C. Larsson, and M. Sommarin (1999)
J. Biol. Chem. 274, 38232-38240
   Abstract »    Full Text »    PDF »
Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp.
C. R. L. Webster and M. S. Anwer (1999)
Am J Physiol Gastrointest Liver Physiol 277, G1165-G1172
   Abstract »    Full Text »    PDF »
Modulation of Endocytic Traffic in Polarized Madin-Darby Canine Kidney Cells by the Small GTPase RhoA.
S.-M. Leung, R. Rojas, C. Maples, C. Flynn, W. G. Ruiz, T.-S. Jou, and G. Apodaca (1999)
Mol. Biol. Cell 10, 4369-4384
   Abstract »    Full Text »
Complementation Analysis in PtdInsP Kinase-deficient Yeast Mutants Demonstrates That Schizosaccharomyces pombe and Murine Fab1p Homologues Are Phosphatidylinositol 3-Phosphate 5-Kinases.
R. K. McEwen, S. K. Dove, F. T. Cooke, G. F. Painter, A. B. Holmes, A. Shisheva, Y. Ohya, P. J. Parker, and R. H. Michell (1999)
J. Biol. Chem. 274, 33905-33912
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The SH3 Domains of Endophilin and Amphiphysin Bind to the Proline-rich Region of Synaptojanin 1 at Distinct Sites That Display an Unconventional Binding Specificity.
G. Cestra, L. Castagnoli, L. Dente, O. Minenkova, A. Petrelli, N. Migone, U. Hoffmuller, J. Schneider-Mergener, and G. Cesareni (1999)
J. Biol. Chem. 274, 32001-32007
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Posttranscriptional regulation of the proximal tubule NaPi-II transporter in response to PTH and dietary Pi.
H. Murer, I. Forster, N. Hernando, G. Lambert, M. Traebert, and J. Biber (1999)
Am J Physiol Renal Physiol 277, F676-F684
   Abstract »    Full Text »    PDF »
Relationship between Phosphatidic Acid Level and Regulation of Protein Transit in Colonic Epithelial Cell Line HT29-cl19A.
R. Auger, P. Robin, B. Camier, G. Vial, B. Rossignol, J.-P. Tenu, and M.-N. Raymond (1999)
J. Biol. Chem. 274, 28652-28659
   Abstract »    Full Text »    PDF »
Ischemic Cell Death in Brain Neurons.
P. Lipton (1999)
Physiol Rev 79, 1431-1568
   Abstract »    Full Text »    PDF »
Inhibition of beta 2-Adrenergic and Muscarinic Cholinergic Receptor Endocytosis after Depletion of Phosphatidylinositol Bisphosphate.
S. D. Sorensen, D. A. Linseman, E. L. McEwen, A. M. Heacock, and S. K. Fisher (1999)
J. Pharmacol. Exp. Ther. 290, 603-610
   Abstract »    Full Text »
p125 Is a Novel Mammalian Sec23p-interacting Protein with Structural Similarity to Phospholipid-modifying Proteins.
K. Tani, T. Mizoguchi, A. Iwamatsu, K. Hatsuzawa, and M. Tagaya (1999)
J. Biol. Chem. 274, 20505-20512
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The Identification of Phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and Its Regulation by Interleukin-2.
D. R. Jones, A. Gonzalez-Garcia, E. Diez, C. Martinez-A., A. C. Carrera, and I. Merida (1999)
J. Biol. Chem. 274, 18407-18413
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Acute cholesterol depletion inhibits clathrin-coated pit budding.
A. Subtil, I. Gaidarov, K. Kobylarz, M. A. Lampson, J. H. Keen, and T. E. McGraw (1999)
PNAS 96, 6775-6780
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Evidence for Apical Endocytosis in Polarized Hepatic Cells: Phosphoinositide 3-Kinase Inhibitors Lead to the Lysosomal Accumulation of Resident Apical Plasma Membrane Proteins.
P. L. Tuma, C. M. Finnegan, J.-H. Yi, and A. L. Hubbard (1999)
J. Cell Biol. 145, 1089-1102
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Splice Variants of Intersectin Are Components of the Endocytic Machinery in Neurons and Nonneuronal Cells.
N. K. Hussain, M. Yamabhai, A. R. Ramjaun, A. M. Guy, D. Baranes, J. P. O'Bryan, C. J. Der, B. K. Kay, and P. S. McPherson (1999)
J. Biol. Chem. 274, 15671-15677
   Abstract »    Full Text »    PDF »


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