Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 March 1996:
Vol. 271. no. 5255, pp. 1586 - 1589
DOI: 10.1126/science.271.5255.1586
Prev | Table of Contents | Next

Reports

Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists

David W. Self, * William J. Barnhart, David A. Lehman, Eric J. Nestler

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this ``priming'' effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06508, USA.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Context-induced relapse to drug seeking: a review.
H. S Crombag, J. M Bossert, E. Koya, and Y. Shaham (2008)
Phil Trans R Soc B 363, 3233-3243
   Abstract »    Full Text »    PDF »
Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knock-Out Mice.
S. B. Caine, M. Thomsen, K. I. Gabriel, J. S. Berkowitz, L. H. Gold, G. F. Koob, S. Tonegawa, J. Zhang, and M. Xu (2007)
J. Neurosci. 27, 13140-13150
   Abstract »    Full Text »    PDF »
Opposing Regulation of Pair Bond Formation by cAMP Signaling within the Nucleus Accumbens Shell.
B. J. Aragona and Z. Wang (2007)
J. Neurosci. 27, 13352-13356
   Abstract »    Full Text »    PDF »
Amphetamine-Induced Dopamine Release: Markedly Blunted in Cocaine Dependence and Predictive of the Choice to Self-Administer Cocaine.
D. Martinez, R. Narendran, R. W. Foltin, M. Slifstein, D.-R. Hwang, A. Broft, Y. Huang, T. B. Cooper, M. W. Fischman, H. D. Kleber, et al. (2007)
Am J Psychiatry 164, 622-629
   Abstract »    Full Text »    PDF »
c-Fos Facilitates the Acquisition and Extinction of Cocaine-Induced Persistent Changes.
J. Zhang, L. Zhang, H. Jiao, Q. Zhang, D. Zhang, D. Lou, J. L. Katz, and M. Xu (2006)
J. Neurosci. 26, 13287-13296
   Abstract »    Full Text »    PDF »
Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal..
E. H. Chartoff, S. D. Mague, M. F. Barhight, A. M. Smith, and W. A. Carlezon Jr (2006)
J. Neurosci. 26, 6450-6457
   Abstract »    Full Text »    PDF »
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.
K.-W. Lee, Y. Kim, A. M. Kim, K. Helmin, A. C. Nairn, and P. Greengard (2006)
PNAS 103, 3399-3404
   Abstract »    Full Text »    PDF »
Medication Development for Addictive Disorders: The State of the Science.
F. J. Vocci, J. Acri, and A. Elkashef (2005)
Am J Psychiatry 162, 1432-1440
   Abstract »    Full Text »    PDF »
Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors.
H. Mizoguchi, K. Yamada, M. Mizuno, T. Mizuno, A. Nitta, Y. Noda, and T. Nabeshima (2004)
Mol. Pharmacol. 65, 1293-1301
   Abstract »    Full Text »
Modification by Dopaminergic Drugs of Choice Behavior under Concurrent Schedules of Intravenous Saline and Food Delivery in Monkeys.
M. Gasior, C. A. Paronis, and J. Bergman (2004)
J. Pharmacol. Exp. Ther. 308, 249-259
   Abstract »    Full Text »    PDF »
A Critical Role for Nucleus Accumbens Dopamine in Partner-Preference Formation in Male Prairie Voles.
B. J. Aragona, Y. Liu, J. T. Curtis, F. K. Stephan, and Z. Wang (2003)
J. Neurosci. 23, 3483-3490
   Abstract »    Full Text »    PDF »
Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats.
S. R. Vorel, C. R. Ashby Jr, M. Paul, X. Liu, R. Hayes, J. J. Hagan, D. N. Middlemiss, G. Stemp, and E. L. Gardner (2002)
J. Neurosci. 22, 9595-9603
   Abstract »    Full Text »    PDF »
Psychomotor Stimulant Addiction: A Neural Systems Perspective.
B. J. Everitt and M. E. Wolf (2002)
J. Neurosci. 22, 3312-3320
   Full Text »    PDF »
D1/D5 Dopamine Receptors Stimulate Intracellular Calcium Release in Primary Cultures of Neocortical and Hippocampal Neurons.
N. Lezcano and C. Bergson (2002)
J Neurophysiol 87, 2167-2175
   Abstract »    Full Text »    PDF »
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens.
W.-K. Park, A. A. Bari, A. R. Jey, S. M. Anderson, R. D. Spealman, J. K. Rowlett, and R. C. Pierce (2002)
J. Neurosci. 22, 2916-2925
   Abstract »    Full Text »    PDF »
Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists.
S. B. Caine, S. S. Negus, N. K. Mello, S. Patel, L. Bristow, J. Kulagowski, D. Vallone, A. Saiardi, and E. Borrelli (2002)
J. Neurosci. 22, 2977-2988
   Abstract »    Full Text »    PDF »
Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review.
U. Shalev, J. W. Grimm, and Y. Shaham (2002)
Pharmacol. Rev. 54, 1-42
   Abstract »    Full Text »    PDF »
Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats.
R. Ito, J. W. Dalley, S. R. Howes, T. W. Robbins, and B. J. Everitt (2000)
J. Neurosci. 20, 7489-7495
   Abstract »    Full Text »    PDF »
Dopamine D1- and D2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior: Effects of Selective Antagonists and Agonists.
T. V. Khroyan, R. L. Barrett-Larimore, J. K. Rowlett, and R. D. Spealman (2000)
J. Pharmacol. Exp. Ther. 294, 680-687
   Abstract »    Full Text »
Dopamine D1 Agonist Activates Temporal Lobe Structures in Primates.
K. J. Black, T. Hershey, M. H. Gado, and J. S. Perlmutter (2000)
J Neurophysiol 84, 549-557
   Abstract »    Full Text »    PDF »
Fos Protein Expression and Cocaine-Seeking Behavior in Rats after Exposure to a Cocaine Self-Administration Environment.
J. L. Neisewander, D. A. Baker, R. A. Fuchs, L. T. L. Tran-Nguyen, A. Palmer, and J. F. Marshall (2000)
J. Neurosci. 20, 798-805
   Abstract »    Full Text »    PDF »
Attenuation of the Euphoric Effects of Cocaine by the Dopamine D1/D5 Antagonist Ecopipam (SCH 39166).
M. K. Romach, P. Glue, K. Kampman, H. L. Kaplan, G. R. Somer, S. Poole, L. Clarke, V. Coffin, J. Cornish, C. P. O'Brien, et al. (1999)
Arch Gen Psychiatry 56, 1101-1106
   Abstract »    Full Text »    PDF »
Effects of Dopamine D1-like and D2-like Agonists in Rats that Self-Administer Cocaine.
S. B. Caine, S. S. Negus, N. K. Mello, and J. Bergman (1999)
J. Pharmacol. Exp. Ther. 291, 353-360
   Abstract »    Full Text »
Reinforcing Effects of Psychostimulants in Humans Are Associated with Increases in Brain Dopamine and Occupancy of D2 Receptors.
N. D. Volkow, G.-J. Wang, J. S. Fowler, J. Logan, S. J. Gatley, C. Wong, R. Hitzemann, and N. R. Pappas (1999)
J. Pharmacol. Exp. Ther. 291, 409-415
   Abstract »    Full Text »
Caffeine, Acting on Adenosine A1 Receptors, Prevents the Extinction of Cocaine-Seeking Behavior in Mice.
A. Kuzmin, B. Johansson, E. E. Zvartau, and B. B. Fredholm (1999)
J. Pharmacol. Exp. Ther. 290, 535-542
   Abstract »    Full Text »
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use.
B. B. Fredholm, K. Battig, J. Holmen, A. Nehlig, and E. E. Zvartau (1999)
Pharmacol. Rev. 51, 83-133
   Abstract »    Full Text »    PDF »
Declarative and Procedural Memory Functioning in Abstinent Cocaine Abusers.
W. G. van Gorp, J. N. Wilkins, C. H. Hinkin, L. H. Moore, J. Hull, M. D. Horner, and D. Plotkin (1999)
Arch Gen Psychiatry 56, 85-89
   Abstract »    Full Text »    PDF »
The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats.
S. Erb, Y. Shaham, and J. Stewart (1998)
J. Neurosci. 18, 5529-5536
   Abstract »    Full Text »    PDF »
Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Self-Administration and Relapse of Cocaine-Seeking Behavior.
D. W. Self, L. M. Genova, B. T. Hope, W. J. Barnhart, J. J. Spencer, and E. J. Nestler (1998)
J. Neurosci. 18, 1848-1859
   Abstract »    Full Text »    PDF »
A role for sensitization in craving and relapse in cocaine addiction.
P. W. Kalivas, R. Chris Pierce, J. Cornish, and B. A. Sorg (1998)
J Psychopharmacol 12, 49-53
   Abstract »    PDF »
Whole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons.
X.-F. Zhang, X.-T. Hu, and F. J. White (1998)
J. Neurosci. 18, 488-498
   Abstract »    Full Text »    PDF »
Dopamine Receptors: From Structure to Function.
C. MISSALE, S. R. NASH, S. W. ROBINSON, M. JABER, and M. G. CARON (1998)
Physiol Rev 78, 189-225
   Abstract »    Full Text »    PDF »
Drug Abuse: Hedonic Homeostatic Dysregulation.
G. F. Koob and M. L. Moal (1997)
Science 278, 52-58
   Abstract »    Full Text »
Molecular and Cellular Basis of Addiction.
E. J. Nestler and G. K. Aghajanian (1997)
Science 278, 58-63
   Abstract »    Full Text »
Psychiatry.
P. M. Marzuk and J. D. Barchas (1997)
JAMA 277, 1892-1894
   PDF »
Science, medicine, and the future: Substance use disorders.
M. A Schuckit (1997)
BMJ 314, 1605
   Full Text »
D2 Dopamine Receptor A1 Allele in Alzheimer Disease and Aging.
G. W. Small, E. P. Noble, S. S. Matsuyama, L. F. Jarvik, S. Komo, A. Kaplan, T. Ritchie, M. L. Pritchard, A. M. Saunders, P. M. Conneally, et al. (1997)
Arch Neurol 54, 281-285
   Abstract »    PDF »
Differential Reinforcing Effects of Cocaine and GBR-12909: Biochemical Evidence for Divergent Neuroadaptive Changes in the Mesolimbic Dopaminergic System.
S. R. Tella, B. Ladenheim, A. M. Andrews, S. R. Goldberg, and J. L. Cadet (1996)
J. Neurosci. 16, 7416-7427
   Abstract »    Full Text »    PDF »
Effects of Binge Pattern Cocaine Administration on Dopamine D1 and D2 Receptors in the Rat Brain: An In Vivo Study Using Positron Emission Tomography.
H. Tsukada, J. Kreuter, C. E. Maggos, E. M. Unterwald, T. Kakiuchi, S. Nishiyama, M. Futatsubashi, and M. J. Kreek (1996)
J. Neurosci. 16, 7670-7677
   Abstract »    Full Text »    PDF »
Adaptive Increase in D3 Dopamine Receptors in the Brain Reward Circuits of Human Cocaine Fatalities.
J. K. Staley and D. C. Mash (1996)
J. Neurosci. 16, 6100-6106
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Cocaine Addiction.
A. I. Leshner (1996)
N. Engl. J. Med. 335, 128-129
   Full Text »    PDF »
ZIC2 and Sp3 Repress Sp1-induced Activation of the Human D1ADopamine Receptor Gene.
Y. Yang, C. K. Hwang, E. Junn, G. Lee, and M. M. Mouradian (2000)
J. Biol. Chem. 275, 38863-38869
   Abstract »    Full Text »    PDF »
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction.
J. L. Cornish and P. W. Kalivas (2000)
J. Neurosci. 20, RC89
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)