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Science 5 April 1996:
Vol. 272. no. 5258, pp. 60 - 67
DOI: 10.1126/science.272.5258.60

Articles

Lymphocyte Homing and Homeostasis

Eugene C. Butcher and Louis J. Picker

The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte ``homing'' process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial ``decision processes'' involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed.

E. C. Butcher is in the Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305- 5324, USA, and the Center for Molecular Biology and Medicine, the Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. L. J. Picker is in the Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235- 9072, USA.



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Chemotactic Factors in Cerebrospinal Fluid during Bacterial Meningitis.
P. J. G. Zwijnenburg, T. van der Poll, J. J. Roord, and A. M. van Furth (2006)
Infect. Immun. 74, 1445-1451
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Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis.
I. J. Crane, H. Xu, C. Wallace, A. Manivannan, M. Mack, J. Liversidge, G. Marquez, P. F. Sharp, and J. V. Forrester (2006)
J. Leukoc. Biol. 79, 435-443
   Abstract »    Full Text »    PDF »
T Cell Chemotaxis and Chemokine Release after Staphylococcus aureus Interaction with Polarized Airway Epithelium.
S. Escotte, D. Al Alam, R. Le Naour, E. Puchelle, M. Guenounou, and S. C. Gangloff (2006)
Am. J. Respir. Cell Mol. Biol. 34, 348-354
   Abstract »    Full Text »    PDF »
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.
J. A. Burger and T. J. Kipps (2006)
Blood 107, 1761-1767
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Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine.
E. Waldman, S. X. Lu, V. M. Hubbard, A. A. Kochman, J. M. Eng, T. H. Terwey, S. J. Muriglan, T. D. Kim, G. Heller, G. F. Murphy, et al. (2006)
Blood 107, 1703-1711
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Lymphoid B cells induce NF-{kappa}B activation in high endothelial cells from human tonsils.
R. Naves, L. I. Reyes, M. Rosemblatt, S. Jacobelli, A. Gonzalez, and M. R. Bono (2006)
Int. Immunol. 18, 259-267
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Enhanced FTY720-Mediated Lymphocyte Homing Requires G{alpha}i Signaling and Depends on beta2 and beta7 Integrin.
O. Pabst, H. Herbrand, S. Willenzon, T. Worbs, A. Schippers, W. Muller, G. Bernhardt, and R. Forster (2006)
J. Immunol. 176, 1474-1480
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Dopamine Selectively Induces Migration and Homing of Naive CD8+ T Cells via Dopamine Receptor D3.
Y. Watanabe, T. Nakayama, D. Nagakubo, K. Hieshima, Z. Jin, F. Katou, K. Hashimoto, and O. Yoshie (2006)
J. Immunol. 176, 848-856
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Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
E. Menu, H. Jernberg-Wiklund, T. Stromberg, H. De Raeve, L. Girnita, O. Larsson, M. Axelson, K. Asosingh, K. Nilsson, B. Van Camp, et al. (2006)
Blood 107, 655-660
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HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro.
M. Montano, M. Rarick, P. Sebastiani, P. Brinkmann, J. Skefos, and R. Ericksen (2006)
Int. Immunol. 18, 125-137
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Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node.
V. Carriere, R. Colisson, C. Jiguet-Jiglaire, E. Bellard, G. Bouche, T. Al Saati, F. Amalric, J.-P. Girard, and C. M'Rini (2005)
Cancer Res. 65, 11639-11648
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Oral and Nasal Sensitization Promote Distinct Immune Responses and Lung Reactivity in a Mouse Model of Peanut Allergy.
R. Fischer, J. R. McGhee, H. L. Vu, T. P. Atkinson, R. J. Jackson, D. Tome, and P. N. Boyaka (2005)
Am. J. Pathol. 167, 1621-1630
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Human CD8+ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation.
O. Gasser, A. Missiou, C. Eken, and C. Hess (2005)
Blood 106, 3718-3724
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Critical Requirement of CD11b (Mac-1) on T Cells and Accessory Cells for Development of Experimental Autoimmune Encephalomyelitis.
D. C. Bullard, X. Hu, T. R. Schoeb, R. C. Axtell, C. Raman, and S. R. Barnum (2005)
J. Immunol. 175, 6327-6333
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Durable Human Memory T Cells Quantifiable by Cultured Enzyme-Linked Immunospot Assays Are Induced by Heterologous Prime Boost Immunization and Correlate with Protection against Malaria.
S. M. Keating, P. Bejon, T. Berthoud, J. M. Vuola, S. Todryk, D. P. Webster, S. J. Dunachie, V. S. Moorthy, S. J. McConkey, S. C. Gilbert, et al. (2005)
J. Immunol. 175, 5675-5680
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Crk-Associated Substrate Lymphocyte Type Is Required for Lymphocyte Trafficking and Marginal Zone B Cell Maintenance.
S. Seo, T. Asai, T. Saito, T. Suzuki, Y. Morishita, T. Nakamoto, M. Ichikawa, G. Yamamoto, M. Kawazu, T. Yamagata, et al. (2005)
J. Immunol. 175, 3492-3501
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Transforming Growth Factor {beta}1 Production by CD4+ CD25+ Regulatory T Cells in Peripheral Blood Mononuclear Cells from Healthy Subjects Stimulated with Leishmania guyanensis.
A. Kariminia, E. Bourreau, H. Pascalis, P. Couppie, D. Sainte-Marie, F. Tacchini-Cottier, and P. Launois (2005)
Infect. Immun. 73, 5908-5914
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Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.
Y. Morimoto, Y. Bian, P. Gao, Y. Yashiro-Ohtani, X.-Y. Zhou, S. Ono, H. Nakahara, M. Kogo, T. Hamaoka, and H. Fujiwara (2005)
J. Leukoc. Biol. 78, 753-761
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