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Science 5 April 1996: Vol. 272. no. 5258, pp. 60 - 67 DOI: 10.1126/science.272.5258.60
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Articles
Lymphocyte Homing and Homeostasis
Eugene C. Butcher
and
Louis J. Picker
The integration and control of systemic immune responses depends on
the regulated trafficking of lymphocytes. This lymphocyte
``homing'' process disperses the immunologic repertoire, directs
lymphocyte subsets to the specialized microenvironments that control
their differentiation and regulate their survival, and targets immune
effector cells to sites of antigenic or microbial invasion. Recent
advances reveal that the exquisite specificity of lymphocyte homing is
determined by combinatorial ``decision processes'' involving
multistep sequential engagement of adhesion and signaling receptors.
These homing-related interactions are seamlessly integrated into the
overall interaction of the lymphocyte with its environment and
participate directly in the control of lymphocyte function, life-span,
and population dynamics. In this article a review of the molecular
basis of lymphocyte homing is presented, and mechanisms by which homing
physiology regulates the homeostasis of immunologic resources are
proposed.
E. C. Butcher is in the Laboratory of Immunology and Vascular
Biology, Department of Pathology, Stanford University School of
Medicine, Stanford, CA 94305- 5324, USA, and the Center for
Molecular Biology and Medicine, the Veterans Affairs Palo Alto Health
Care System, Palo Alto, CA 94304, USA. L. J. Picker is in the
Laboratory of Molecular Pathology, Department of Pathology, University
of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard,
Dallas, TX 75235- 9072, USA.
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J. Med. Microbiol.
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- Contrasting Roles for Domain 4 of VCAM-1 in the Regulation of Cell Adhesion and Soluble VCAM-1 Binding to Integrin {alpha}4beta1..
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176, 5041-5049
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- CXCL10 Is the Key Ligand for CXCR3 on CD8+ Effector T Cells Involved in Immune Surveillance of the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System.
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176, 4235-4243
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- Monitoring the Antitumor Response of Naive and Memory CD8 T Cells in RAG1-/- Mice by Positron-Emission Tomography.
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176, 4459-4467
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- A Tumor Necrosis Factor Receptor 1-Dependent Conversation between Central Nervous System-Specific T Cells and the Central Nervous System Is Required for Inflammatory Infiltration of the Spinal Cord.
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168, 1200-1209
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- Chemotactic Factors in Cerebrospinal Fluid during Bacterial Meningitis.
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Infect. Immun.
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- Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis.
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- T Cell Chemotaxis and Chemokine Release after Staphylococcus aureus Interaction with Polarized Airway Epithelium.
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- CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.
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Blood
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- Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine.
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Blood
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- Lymphoid B cells induce NF-{kappa}B activation in high endothelial cells from human tonsils.
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- Enhanced FTY720-Mediated Lymphocyte Homing Requires G{alpha}i Signaling and Depends on beta2 and beta7 Integrin.
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- Dopamine Selectively Induces Migration and Homing of Naive CD8+ T Cells via Dopamine Receptor D3.
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- Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
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Blood
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- Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node.
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- Durable Human Memory T Cells Quantifiable by Cultured Enzyme-Linked Immunospot Assays Are Induced by Heterologous Prime Boost Immunization and Correlate with Protection against Malaria.
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- Crk-Associated Substrate Lymphocyte Type Is Required for Lymphocyte Trafficking and Marginal Zone B Cell Maintenance.
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- Transforming Growth Factor {beta}1 Production by CD4+ CD25+ Regulatory T Cells in Peripheral Blood Mononuclear Cells from Healthy Subjects Stimulated with Leishmania guyanensis.
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