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Science 5 April 1996:
Vol. 272. no. 5258, pp. 67 - 74
DOI: 10.1126/science.272.5258.67
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Articles

Population Biology of Antigen Presentation by MHC Class I Molecules

Peter Parham and Tomoko Ohta

In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology: How does the immune response emerge from the interactions among populations of peptides, T cells, and MHC molecules? Within a population of vertebrates, how does MHC polymorphism stamp individuality on the response? Does polymorphism confer differential advantages in responding to parasites? How are the pressures on the MHC reflected in turnover of alleles? The role of mutation, recombination, selection, and drift in the generation and maintenance of MHC class I polymorphism are considered.

P. Parham is in the Department of Structural Biology, Stanford University, Stanford, CA 94305, USA. T. Ohta is at the National Institute of Genetics, Graduate University for Advanced Studies, Mishima, Shizuoka-ken 411, Japan.


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