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Science 5 April 1996:
Vol. 272. no. 5258, pp. 74 - 79
DOI: 10.1126/science.272.5258.74
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Articles

Population Dynamics of Immune Responses to Persistent Viruses

Martin A. Nowak and Charles R. M. Bangham

Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).

M. A. Nowak is in the Department of Zoology, University of Oxford, South Parks Road, OX1 3PS Oxford, UK. E-mail: nowak{at}vax.ox.ac.uk. C. R. M. Bangham is in the Imperial College School of Medicine at St. Mary's, Norfolk Place, London W2 1PG, UK. E-mail: c.bangham{at}ic.ac.uk


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