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Science 24 May 1996:
Vol. 272. no. 5265, pp. 1126 - 1131
DOI: 10.1126/science.272.5265.1126
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Articles

The Cerebellum: A Neuronal Learning Machine?

Jennifer L. Raymond, Stephen G. Lisberger, Michael D. Mauk *

Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning. Behavioral and physiological data about classical conditioning of the eyelid response and motor learning in the vestibulo-ocular reflex suggest that (i) plasticity is distributed between the cerebellar cortex and the deep cerebellar nuclei; (ii) the cerebellar cortex plays a special role in learning the timing of movement; and (iii) the cerebellar cortex guides learning in the deep nuclei, which may allow learning to be transferred from the cortex to the deep nuclei. Because many of the similarities in the data from the two systems typify general features of cerebellar organization, the cerebellar mechanisms of learning in these two systems may represent principles that apply to many motor systems.

J. L. Raymond is in the Department of Physiology and the W. M. Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA. S. G. Lisberger is in the Department of Physiology, the W. M. Keck Foundation Center for Integrative Neuroscience, and the Sloan Center for Theoretical Neurobiology, University of California, San Francisco, CA 94143, USA. M. D. Mauk is in the Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA.
* To whom correspondence should be addressed.


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Neural Learning Rules for the Vestibulo-Ocular Reflex.
J. L. Raymond and S. G. Lisberger (1998)
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Effects of Lesions of the Oculomotor Vermis on Eye Movements in Primate: Saccades.
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Changes in Brain Activity During Motor Learning Measured With PET: Effects of Hand of Performance and Practice.
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J Neurophysiol 78, 1030-1044
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Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.
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Multiple subclasses of purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflex..
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Conditioned response timing and integration in the cerebellum..
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PNAS 93, 13435-13437
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Cerebellar cortical inhibition and classical eyeblink conditioning.
S. Bao, L. Chen, J. J. Kim, and R. F. Thompson (2002)
PNAS 99, 1592-1597
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Parallel Fibers Synchronize Spontaneous Activity in Cerebellar Golgi Cells.
B. P. Vos, R. Maex, A. Volny-Luraghi, and E. D. Schutter (1999)
J. Neurosci. 19, RC6
   Abstract »    Full Text »    PDF »


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