Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 June 1996:
Vol. 272. no. 5270, pp. 1904 - 0
DOI: 10.1126/science.272.5270.1904
Prev | Table of Contents | Next

Perspectives

Rafi Ahmed

Viruses cause immediate induction of type I interferons (which include IFN-alpha and IFN-beta). These IFN I cytokines limit spread of the virus until antigen-specific responses can fully control the infection. A report by Tough et al. (p. 1947) show that these IFN I have another function: They also augment the proliferation of T cells, including a subset of T cells that may mediate long-term immunological memory. In his Perspective, Ahmed discusses the possible contribution of this bystander effect of IFN I to immunological memory.

The author is at the Emory Vaccine Center, Emory University School of Medicine, G211 Rollins Research Building, Atlanta, GA 30322, USA. E-mail: holcombe{at}microbio.emory.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of T-Lymphocyte Depletion on Muscle Fibrosis in the mdx Mouse.
J. Morrison, D. B. Palmer, S. Cobbold, T. Partridge, and G. Bou-Gharios (2005)
Am. J. Pathol. 166, 1701-1710
   Abstract »    Full Text »    PDF »
Memorizing innate instructions requires a sufficiently specific adaptive immune system.
J. A. M. Borghans and R. J. De Boer (2002)
Int. Immunol. 14, 525-532
   Abstract »    Full Text »    PDF »
Interferon-{alpha} as an immunotherapeutic protein.
D. L. Brassard, M. J. Grace, and R. W. Bordens (2002)
J. Leukoc. Biol. 71, 565-581
   Abstract »    Full Text »    PDF »
A central role for thymic emigrants in peripheral T cell homeostasis.
S. P. Berzins, D. I. Godfrey, J. F. A. P. Miller, and R. L. Boyd (1999)
PNAS 96, 9787-9791
   Abstract »    Full Text »    PDF »
In Vivo Treatment with a MHC Class I-Restricted Blocking Peptide Can Prevent Virus-Induced Autoimmune Diabetes.
M. G. von Herrath, B. Coon, H. Lewicki, H. Mazarguil, J. E. Gairin, and M. B. A. Oldstone (1998)
J. Immunol. 161, 5087-5096
   Abstract »    Full Text »    PDF »
The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool.
S.P. Berzins, R.L. Boyd, and J.F.A.P. Miller (1998)
J. Exp. Med. 187, 1839-1848
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)