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Science 26 July 1996:
Vol. 273. no. 5274, pp. 494 - 497
DOI: 10.1126/science.273.5274.494
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Reports

Multicolor Spectral Karyotyping of Human Chromosomes

E. Schröck, S. du Manoir, T. Veldman, B. Schoell, J. Wienberg, M. A. Ferguson-Smith, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soenksen, Y. Garini, T. Ried *

The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.

E. Schröck, S. du Manoir, T. Veldman, B. Schoell, Y. Ning, D. H. Ledbetter, T. Ried, Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, 49 Convent Drive, Building 49, Room 4A28, Bethesda, MD 20892-4470, USA.
J. Wienberg and M. A. Ferguson-Smith, Department of Pathology, Cambridge University, Cambridge CB21QP, UK.
I. Bar-Am, Department of Cell Research and Immunology, Tel-Aviv University, Tel Aviv 69978, Israel.
D. Soenksen, Applied Spectral Imaging, Incorporated, Carlsbad, CA 92009, USA.
Y. Garini, Applied Spectral Imaging, Limited, Migdal Haemek, 10551 Israel.
*   To whom correspondence should be addressed. E-mail: tried{at}nchgr.nih.gov


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H. Ding, L. Roncari, P. Shannon, X. Wu, N. Lau, J. Karaskova, D. H. Gutmann, J. A. Squire, A. Nagy, and A. Guha (2001)
Cancer Res. 61, 3826-3836
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Unraveling human cancer in the mouse: recent refinements to modeling and analysis.
L. Resor, T. J. Bowen, and A. Wynshaw-Boris (2001)
Hum. Mol. Genet. 10, 669-675
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Molecular cytogenetic characterisation of a complex 46,XY,t(7;8;11;13) chromosome rearrangement in a patient with Moebius syndrome.
G BORCK, J WIRTH, T HARDT, H TÖNNIES, K BRØNDUM-NIELSEN, M BUGGE, N TOMMERUP, H-G NOTHWANG, H-H ROPERS, and T HAAF (2001)
J. Med. Genet. 38, 117-121
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Human Papillomavirus Type 16 E6 Inactivation of p53 in Normal Human Mammary Epithelial Cells Promotes Tamoxifen-mediated Apoptosis.
V. L. Seewaldt, K. Mrózek, E. C. Dietze, M. Parker, and L. E. Caldwell (2001)
Cancer Res. 61, 616-624
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