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Science 21 July 2000:
Vol. 289. no. 5478, pp. 463 - 465
DOI: 10.1126/science.289.5478.463
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Reports

Abolition and Reversal of Strain Differences in Behavioral Responses to Drugs of Abuse After a Brief Experience

Simona Cabib,1 Cristina Orsini,1 Michel Le Moal,2 Pier Vincenzo Piazza2*

Inbred strains of mice are largely used to identify the genetic basis of normal and pathological behaviors. This report demonstrates that a moderate period of food shortage, an ecologically common experience, can reverse or abolish strain differences in behavioral responses to the abused psychostimulant amphetamine. The period of food shortage occurred when the animals were mature and was terminated before the administration of amphetamine. Strain differences in behavior appear highly dependent on environmental experiences. Consequently, to identify biological determinants of behavior, an integrated approach considering the interaction between environmental and genetic factors needs to be used.

1 Dipartimento di Psicologia, Università "La Sapienza" via dei Marsi 78, Roma I-00185, Italy.
2 Laboratoire de Psychobiologie des Comportement Adaptatifs, INSERM Unit 259, Institute François Magendie, University of Bordeaux II, Rue Camille St. Saens, Domaine de Carreire, Bordeaux Cedex, France.
*   To whom correspondence should be addressed. E-mail: pier-vincenzo.piazza{at}bordeaux.inserm.fr

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