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Science 10 November 1995:
Vol. 270. no. 5238, pp. 915 - 916
DOI: 10.1126/science.270.5238.915
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Research News

Stephen S. Hall

When they were first produced 2 decades ago, monoclonal antibodies were enthusiastically touted as "magic bullets" that would find wide application in medical therapeutics and diagnostics. But a variety of problems including severe immune reactions prevented them from living up to the early hype. A recent conference on monoclonals and cancer therapy suggests, however, that some of the difficulties are slowly being overcome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Delivery of Systemic Chemotherapeutic Agent to Tumors by Using Focused Ultrasound: Study in a Murine Model.
E. L. Yuh, S. G. Shulman, S. A. Mehta, J. Xie, L. Chen, V. Frenkel, M. D. Bednarski, and K. C. P. Li (2005)
Radiology 234, 431-437
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Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules.
P. A. Netti, L. M. Hamberg, J. W. Babich, D. Kierstead, W. Graham, G. J. Hunter, G. L. Wolf, A. Fischman, Y. Boucher, and R. K. Jain (1999)
PNAS 96, 3137-3142
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A Monoclonal Antibody against Rat Calcitonin Inhibits the Growth of a Rat Medullary Thyroid Carcinoma Cell Line in Vitro.
R. Zhang and L. J. DeGroot (1997)
Endocrinology 138, 1697-1703
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The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily.
J. K. Heath, S. J. White, C. N. Johnstone, B. Catimel, R. J. Simpson, R. L. Moritz, G.-F. Tu, H. Ji, R. H. Whitehead, L. C. Groenen, et al. (1997)
PNAS 94, 469-474
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