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Science 19 January 1996:
Vol. 271. no. 5247, pp. 314 - 315
DOI: 10.1126/science.271.5247.314
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Perspectives

Antony M. Carr

Checkpoints are times during the cell cycle when the cell can choose to pause if something is amiss--if its DNA is damaged or if there is a mistake in the synthesis of the new DNA--so that the damage can be repaired. The proteins of these pathways have been defined genetically. Now Carr discusses new biochemical evidence from yeast, presented in two papers in this week's issue of Science (pp. 353 and 357), that start to elucidate the functions of two of these proteins--Chk1 and Rad3.

The author is in the Medical Research Council Cell Mutation Unit, Sussex University, BN1 9RR, UK. E-mail: a.m.carr@sussex.ac.uk


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein.
V. Gottifredi, O. Karni-Schmidt, S.-Y. Shieh, and C. Prives (2001)
Mol. Cell. Biol. 21, 1066-1076
   Abstract »    Full Text »    PDF »
Analysis of Fission Yeast Primase Defines the Checkpoint Responses to Aberrant S Phase Initiation.
S. Tan and T. S.-F. Wang (2000)
Mol. Cell. Biol. 20, 7853-7866
   Abstract »    Full Text »    PDF »
Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice.
H. Takai, K. Tominaga, N. Motoyama, Y. A. Minamishima, H. Nagahama, T. Tsukiyama, K. Ikeda, K. Nakayama, M. Nakanishi, and K.-i. Nakayama (2000)
Genes & Dev. 14, 1439-1447
   Abstract »    Full Text »
An Indolocarbazole Inhibitor of Human Checkpoint Kinase (Chk1) Abrogates Cell Cycle Arrest Caused by DNA Damage.
J. R. Jackson, A. Gilmartin, C. Imburgia, J. D. Winkler, L. A. Marshall, and A. Roshak (2000)
Cancer Res. 60, 566-572
   Abstract »    Full Text »
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome.
D. W. Bell, J. M. Varley, T. E. Szydlo, D. H. Kang, D. C. Wahrer, K. E. Shannon, M. Lubratovich, S. J. Verselis, K. J. Isselbacher, J. F. Fraumeni, et al. (1999)
Science 286, 2528-2531
   Abstract »    Full Text »
A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system.
B. D. Aguda (1999)
PNAS 96, 11352-11357
   Abstract »    Full Text »    PDF »
Molecular Cloning and Tissue-Specific Expression of the mutator2 Gene (mu2) in Drosophila melanogaster.
A. Kasravi, M. F. Walter, S. Brand, J. M. Mason, and H. Biessmann (1999)
Genetics 152, 1025-1035
   Abstract »    Full Text »
The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts.
A. Kumagai, Z. Guo, K. H. Emami, S. X. Wang, and W. G. Dunphy (1998)
J. Cell Biol. 142, 1559-1569
   Abstract »    Full Text »    PDF »
Specific Mismatch Recognition in Heteroduplex Intermediates by p53 Suggests a Role in Fidelity Control of Homologous Recombination.
C. Dudenhoffer, G. Rohaly, K. Will, W. Deppert, and L. Wiesmuller (1998)
Mol. Cell. Biol. 18, 5332-5342
   Abstract »    Full Text »    PDF »
Mutational Effect of Fission Yeast Polalpha on Cell Cycle Events.
D. Bhaumik and T. S.-F. Wang (1998)
Mol. Biol. Cell 9, 2107-2123
   Abstract »    Full Text »
Disruption of the G1/S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E.
L. G. Martin, G. W. Demers, and D. A. Galloway (1998)
J. Virol. 72, 975-985
   Abstract »    Full Text »    PDF »
The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway.
O. Cohen-Fix and D. Koshland (1997)
PNAS 94, 14361-14366
   Abstract »    Full Text »    PDF »
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae..
T A Navas, Y Sanchez, and S J Elledge (1996)
Genes & Dev. 10, 2632-2643
   Abstract »    PDF »
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes..
K S Keegan, D A Holtzman, A W Plug, E R Christenson, E E Brainerd, G Flaggs, N J Bentley, E M Taylor, M S Meyn, S B Moss, et al. (1996)
Genes & Dev. 10, 2423-2437
   Abstract »    PDF »


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