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Science 26 January 1996:
Vol. 271. no. 5248, p. 447
DOI: 10.1126/science.271.5248.447
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Research News

Wade Roush

In its war against bacterial infections, one of medicine's longtime allies has been a member of the enemy: bacille Calmette-Guérin (BCG). The mycobacterium has been widely used as a vaccine against the tuberculosis (TB) organism. But BCG's protective effect varies greatly and wanes as people age. Now reinforcements may be on the way. Researchers have engineered a BCG strain to express mammalian cytokines, intercellular messengers that rally the immune system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)