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Science 20 September 1996:
Vol. 273. no. 5282, pp. 1660 - 0
DOI: 10.1126/science.273.5282.1660
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Research News

Robert F. Service

Chronic use of aspirin and other so-called nonsteroidal anti-inflammatory drugs (NSAIDs) can cause stomach bleeding, kidney failure, or worse. The problem is that the compounds not only subdue a key enzyme involved in triggering inflammation and pain; they also stifle a nearly identical enzyme that helps maintain tissues such as the stomach lining. Now researchers at a number of drug companies are making progress toward "superaspirins"--compounds capable of discriminating between the twin enzymes, which would enable them to fight pain without causing dangerous side effects.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)