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Science 5 September 2008:
Vol. 321. no. 5894, pp. 1298 - 1299
DOI: 10.1126/science.1160622
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Policy Forum

MEDICINE:
Life Cycle of Translational Research for Medical Interventions

Despina G. Contopoulos-Ioannidis,1 George A. Alexiou,2 Theodore C. Gouvias,2 John P. A. Ioannidis2,3,4*

From the initial discovery of a medical intervention to a highly cited article is a long road, and even this is not the end of the journey.

1Department of Pediatrics, University of Ioannina School of Medicine, Ioannina, 45110, Greece, and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

2Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece

3Department of Medicine, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, MA 02111, USA

4Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece

*Author for correspondence (at the address in footnote 2). E-mail: jioannid{at}cc.uoi.gr; john.pa.ioannidis{at}gmail.com

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